Colorectal cancer is cancer that occurs in the colon or rectum, and affects both men and women of all racial and ethnic groups, and is most often found in people aged 50 years or older. For men, colorectal cancer is the third most common cancer after prostate and lung cancers. For women, colorectal cancer is the third most common cancer after breast and lung cancers.
Fecal occult blood should be an important indicator in the diagnostic evaluation of patients with suspected gastrointestinal bleeding of any etiology, not just as an indication of colorectal cancer. The presence of human haemoglobin in faeces is inadequate as a screening test for stomach cancer (upper gastrointestinal disorders), because of human haemoglobin derived from the upper digestive tract is broken down in the intestinal tract (the antigenicity is lost).
Detection of fecal transferrin, which is more stable in stool than haemoglobin, provides an alternative way of diagnosing the disease in the upper digestive tract.
Blood in the stool may be the only symptom of cancer, but not all blood in the stool is caused by cancer. Other conditions that can cause blood in the stool include: Haemorrhoids, Anal fissures, Colon polyps, Peptic ulcers, Ulcerative colitis. Gastroesophageal reflux disease (GERD). Crohn’s disease, use of non-steroidal anti-inflammatory drugs (NSAIDs).

The FOB-Transferrin Device is a qualitative lateral flow immunoassay for the detection of human haemoglobin and human transferrin in faeces samples. The membrane is pre-coated with monoclonal antibodies against human haemoglobin and human transferrin on the test lines region. During testing, the sample reacts with the particles coated with anti-human haemoglobin and anti-human transferrin antibodies which were pre-dried on the test strip. The mixture moves upward on the membrane by capillary action. In the case of a positive result the specific antibodies present on the membrane will react with the mixture conjugate and generate coloured lines. A green coloured band always appears in the control line and serves as verification that sufficient volume was added, that proper flow was obtained and as an internal control for the reagents.

Product Feature

For FOB:
–High Sensitivity: 99%
–High Specificity: 99%

For Transferrin:

–High Sensitivity: 99%
–High Specificity: 99%
–Ease-to-use
–Reliable results

Ordering Information:
  • 1. Cassette Cat No.: AN1018C
  • 2. Dipstick Cat No.: AN1018S
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